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Publication

Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task.

Hongdian Yang | Bilal A Bari | Jeremiah Y Cohen | Daniel H O'Connor
eLife | 2021

We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.

Pubmed ID: 33721552

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Associated grants

  • Agency: NIMH NIH HHS, United States
    Id: F30 MH110084
  • Agency: NIMH NIH HHS, United States
    Id: F30MH110084
  • Agency: NINDS NIH HHS, United States
    Id: 1R01NS104834-01
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS112200
  • Agency: NINDS NIH HHS, United States
    Id: 1R01NS107355
  • Agency: NINDS NIH HHS, United States
    Id: 1R01NS112200
  • Agency: NINDS NIH HHS, United States
    Id: P30 NS050274
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS107355
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM007309
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM136577
  • Agency: NINDS NIH HHS, United States
    Id: R01NS089652
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS104834
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS089652

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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