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Publication

A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer.

Aayah Nounu | Alexander Greenhough | Kate J Heesom | Rebecca C Richmond | Jie Zheng | Stephanie J Weinstein | Demetrius Albanes | John A Baron | John L Hopper | Jane C Figueiredo | Polly A Newcomb | Noralane M Lindor | Graham Casey | Elizabeth A Platz | Loïc Le Marchand | Cornelia M Ulrich | Christopher I Li | Fränzel J B van Duijnhoven | Andrea Gsur | Peter T Campbell | Víctor Moreno | Pavel Vodicka | Ludmila Vodickova | Hermann Brenner | Jenny Chang-Claude | Michael Hoffmeister | Lori C Sakoda | Martha L Slattery | Robert E Schoen | Marc J Gunter | Sergi Castellví-Bel | Hyeong Rok Kim | Sun-Seog Kweon | Andrew T Chan | Li Li | Wei Zheng | D Timothy Bishop | Daniel D Buchanan | Graham G Giles | Stephen B Gruber | Gad Rennert | Zsofia K Stadler | Tabitha A Harrison | Yi Lin | Temitope O Keku | Michael O Woods | Clemens Schafmayer | Bethany Van Guelpen | Steven Gallinger | Heather Hampel | Sonja I Berndt | Paul D P Pharoah | Annika Lindblom | Alicja Wolk | Anna H Wu | Emily White | Ulrike Peters | David A Drew | Dominique Scherer | Justo Lorenzo Bermejo | Ann C Williams | Caroline L Relton
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology | 2021

Evidence for aspirin's chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new aspirin targets that decrease CRC risk.

Pubmed ID: 33318029

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA067941
  • Agency: NHGRI NIH HHS, United States
    Id: U01 HG004438
  • Agency: NHGRI NIH HHS, United States
    Id: U01 HG004446
  • Agency: NCI NIH HHS, United States
    Id: U10 CA037429
  • Agency: NCI NIH HHS, United States
    Id: K05 CA154337
  • Agency: NCI NIH HHS, United States
    Id: U01 CA164930
  • Agency: NCI NIH HHS, United States
    Id: P30 CA076292
  • Agency: NCI NIH HHS, United States
    Id: R01 CA042182
  • Agency: NCI NIH HHS, United States
    Id: P50 CA127003
  • Agency: NCI NIH HHS, United States
    Id: U01 CA067941
  • Agency: NCI NIH HHS, United States
    Id: R01 CA059045
  • Agency: NHLBI NIH HHS, United States
    Id: HHSN268201100001I
  • Agency: NCI NIH HHS, United States
    Id: R01 CA197350
  • Agency: NCI NIH HHS, United States
    Id: R01 CA076366
  • Agency: NCI NIH HHS, United States
    Id: R35 CA197735
  • Agency: NCI NIH HHS, United States
    Id: R01 CA072520
  • Agency: NCI NIH HHS, United States
    Id: P01 CA087969
  • Agency: NCI NIH HHS, United States
    Id: P30 CA015704
  • Agency: NHLBI NIH HHS, United States
    Id: HHSN268201100004I
  • Agency: NCI NIH HHS, United States
    Id: P30 CA006973
  • Agency: NCI NIH HHS, United States
    Id: U24 CA074783
  • Agency: NCI NIH HHS, United States
    Id: P01 CA055075
  • Agency: NIH HHS, United States
    Id: S10 OD028685
  • Agency: NCI NIH HHS, United States
    Id: R01 CA151993
  • Agency: NHLBI NIH HHS, United States
    Id: HHSN268201100046C
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK034987
  • Agency: NCI NIH HHS, United States
    Id: R01 CA048998
  • Agency: NCI NIH HHS, United States
    Id: U01 CA137088
  • Agency: Cancer Research UK, United Kingdom
    Id: 11975
  • Agency: NCI NIH HHS, United States
    Id: R01 CA189184
  • Agency: NCI NIH HHS, United States
    Id: U01 CA167552
  • Agency: WHI NIH HHS, United States
    Id: HHSN268201100003C
  • Agency: Medical Research Council, United Kingdom
    Id: MC_UU_12013_2
  • Agency: Intramural NIH HHS, United States
    Id: Z01 CP010200
  • Agency: NCI NIH HHS, United States
    Id: U24 CA074794
  • Agency: NCI NIH HHS, United States
    Id: R01 CA066635
  • Agency: NCI NIH HHS, United States
    Id: R21 CA191312
  • Agency: NCI NIH HHS, United States
    Id: U01 CA206110
  • Agency: NHLBI NIH HHS, United States
    Id: HHSN268201200008C
  • Agency: Cancer Research UK, United Kingdom
    Id: C18281/A19169
  • Agency: NCI NIH HHS, United States
    Id: R01 CA137178
  • Agency: NCI NIH HHS, United States
    Id: U01 CA074794
  • Agency: NCI NIH HHS, United States
    Id: P30 CA008748
  • Agency: NCI NIH HHS, United States
    Id: U01 CA167551
  • Agency: NCI NIH HHS, United States
    Id: P30 CA014089
  • Agency: NCI NIH HHS, United States
    Id: R01 CA081488
  • Agency: NIA NIH HHS, United States
    Id: HHSN271201100004C
  • Agency: NCI NIH HHS, United States
    Id: R01 CA201407
  • Agency: NCI NIH HHS, United States
    Id: R01 CA063464
  • Agency: NCI NIH HHS, United States
    Id: P01 CA033619
  • Agency: NCI NIH HHS, United States
    Id: U01 CA086308
  • Agency: NCI NIH HHS, United States
    Id: UM1 CA186107
  • Agency: WHI NIH HHS, United States
    Id: HHSN268201100002C
  • Agency: NCI NIH HHS, United States
    Id: R01 CA207371
  • Agency: NCI NIH HHS, United States
    Id: R03 CA153323
  • Agency: NIEHS NIH HHS, United States
    Id: T32 ES013678
  • Agency: NCI NIH HHS, United States
    Id: R01 CA136726
  • Agency: NCI NIH HHS, United States
    Id: P30 CA016058
  • Agency: NCI NIH HHS, United States
    Id: UM1 CA167552
  • Agency: NCI NIH HHS, United States
    Id: K05 CA152715
  • Agency: NCI NIH HHS, United States
    Id: U01 CA122839
  • Agency: Wellcome Trust, United Kingdom
  • Agency: NHLBI NIH HHS, United States
    Id: HHSN268201100003I
  • Agency: NHLBI NIH HHS, United States
    Id: HHSN268201100002I
  • Agency: NCI NIH HHS, United States
    Id: U01 CA074783
  • Agency: NCI NIH HHS, United States
    Id: U01 CA084968
  • Agency: NCATS NIH HHS, United States
    Id: KL2 TR000421
  • Agency: Medical Research Council, United Kingdom
    Id: MR/R017247/1
  • Agency: NCI NIH HHS, United States
    Id: UM1 CA182883
  • Agency: NCI NIH HHS, United States
    Id: K07 CA190673
  • Agency: NHLBI NIH HHS, United States
    Id: HHSN268201200008I
  • Agency: Wellcome Trust, United Kingdom
    Id: 217487/Z/19/Z
  • Agency: NCI NIH HHS, United States
    Id: U01 CA164973
  • Agency: NCI NIH HHS, United States
    Id: R37 CA054281
  • Agency: WHI NIH HHS, United States
    Id: HHSN268201100001C
  • Agency: WHI NIH HHS, United States
    Id: HHSN268201100004C
  • Agency: NCI NIH HHS, United States
    Id: R01 CA097325
  • Agency: NHLBI NIH HHS, United States
    Id: HHSN268201700006C
  • Agency: NCI NIH HHS, United States
    Id: U19 CA148107
  • Agency: NIA NIH HHS, United States
    Id: U01 AG018033

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S/RG/C2 (cell line)

RRID:CVCL_IQ11

Cell line S/RG/C2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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