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Innate behaviours, although robust and hard wired, rely on modulation of neuronal circuits, for eliciting an appropriate response according to internal states and external cues. Drosophila flight is one such innate behaviour that is modulated by intracellular calcium release through inositol 1,4,5-trisphosphate receptors (IP3Rs). Cellular mechanism(s) by which IP3Rs modulate neuronal function for specific behaviours remain speculative, in vertebrates and invertebrates. To address this, we generated an inducible dominant negative form of the IP3R (IP3RDN). Flies with neuronal expression of IP3RDN exhibit flight deficits. Expression of IP3RDN helped identify key flight-modulating dopaminergic neurons with axonal projections in the mushroom body. Flies with attenuated IP3Rs in these presynaptic dopaminergic neurons exhibit shortened flight bouts and a disinterest in seeking food, accompanied by reduced excitability and dopamine release upon cholinergic stimulation. Our findings suggest that the same neural circuit modulates the drive for food search and for undertaking longer flight bouts.
Pubmed ID: 33155978
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Software application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionsWeb tool for graphical illustrations for biological systems by BioRender. Used for articles and presentations. Collection of pre made icons and templates from life science fields for scientific illustrations. Customized icons possible on request.
View all literature mentionsDrosophila melanogaster with name Canton-S from BDSC.
View all literature mentionsThis polyclonal secondary targets IgG (H+L) Poly-HRP
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis unknown targets IgG (H+L)
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View all literature mentionsThis monoclonal targets Spectrin, alpha
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R22B12-GAL4.DBD}attP2 PBac{y[+mDint2] w[+mC]=ple-p65.AD}VK00027 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; betaTub60D[Pin-Yt]/CyO; P{w[+mC]=UAS-mCD8::GFP.L}LL6 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Itpr[ka1091]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Itpr[ug3]/TM6B, Tb[1] from BDSC.
View all literature mentionsSoftware application for data analysis and graphing. Origin contains a variety of different graph types, including statistical plots, 2D and 3D vector graphs, and counter graphs. More advance version is OriginPro which offers advanced analysis tools and Apps for Peak Fitting, Surface Fitting, Statistics and Signal Processing.
View all literature mentionsBiomaterial supply resource which collects, maintains, and distributes independent transgenic fly lines. Most of the 38,000 fly lines are RNAi lines, but VDRC also maintains a collection of enhancer-GAL4 driver lines. Nearly all lines are in duplicate. Users can search for the stocks or DNA constructs for the gene of interest by entering CG number, synonym, or Transformant ID.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-syt.eGFP}3 from BDSC.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=VT026773-p65.AD}attP40; P{y[+t7.7] w[+mC]=R72B05-GAL4.DBD}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-IVS-GCaMP6m}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; PBac{y[+mDint2] w[+mC]=20XUAS-IVS-GCaMP6m}VK00005 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; PBac{w[+mC]=IT.GAL4}nes[0424-G4] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=10XUAS-IVS-mCD8::RFP}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-Dcr-2.D}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+m*]=nSyb-GAL4.S}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R82C10-p65.AD}attP40; P{y[+t7.7] w[+mC]=R50B03-GAL4.DBD}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R82C10-p65.AD}attP40; P{y[+t7.7] w[+mC]=R26F01-GAL4.DBD}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=UAS-ArcLight}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=13XLexAop2-IVS-CsChrimson.mVenus}attP18 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R30E11-p65.AD}attP40/CyO; P{y[+t7.7] w[+mC]=R22B12-GAL4.DBD}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R52H03-p65.AD}attP40; P{y[+t7.7] w[+mC]=ple-GAL4.DBD}attP2 from BDSC.
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