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Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain.

Mohammed Shaqura | Li Li | Doaa M Mohamed | Xiongjuan Li | Sascha Treskatsch | Constanze Buhrmann | Mehdi Shakibaei | Antje Beyer | Shaaban A Mousa | Michael Schäfer
Journal of neuroinflammation | 2020

Recently, mineralocorticoid receptors (MR) were identified in peripheral nociceptive neurons, and their acute antagonism was responsible for immediate and short-lasting (non-genomic) antinociceptive effects. The same neurons were shown to produce the endogenous ligand aldosterone by the enzyme aldosterone synthase.

Pubmed ID: 32532285

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Ensembl (tool)

RRID:SCR_002344

Collection of genome databases for vertebrates and other eukaryotic species with DNA and protein sequence search capabilities. Used to automatically annotate genome, integrate this annotation with other available biological data and make data publicly available via web. Ensembl tools include BLAST, BLAT, BioMart and the Variant Effect Predictor (VEP) for all supported species.

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RRID:SCR_004286

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RRID:SCR_008392

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RRID:SCR_008452

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RRID:SCR_008539

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RRID:SCR_008988

American chemical, life science and biotechnology company owned by Merck KGaA. Merger of Sigma Chemical Company and Aldrich Chemical Company. Provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.

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RRID:RGD_13508588

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