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Publication

Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt.

Rongjin Sun | Lijun Zhu | Li Li | Wenjie Song | Xia Gong | Xiaoxiao Qi | Ying Wang | Romi Ghose | Song Gao | Ming Hu | Zhongqiu Liu
Toxicology and applied pharmacology | 2020

Irinotecan-induced diarrhea (IID) results from intestinal damages by its active metabolite SN-38. Alleviation of these damages has focused on lowering luminal SN-38 concentrations. However, it is unclear if the enteric bioavailability of SN-38 is mostly dependent on luminal SN-38 concentrations.

Pubmed ID: 32387182

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA246209
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM070737

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Caco-2 (tool)

RRID:CVCL_0025

Cell line Caco-2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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