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Publication

Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor κ B-reactive oxygen species signaling axis.

Lei Wang | Mingming Wang | Hongju Dou | Wenjie Lin | Lifang Zou
Cancer cell international | 2020

Chronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm resulting from BCR-ABL-transformed hematopoietic stem cells. Previous research has implicated multifunctional proinflammatory cytokines in CML development. It has been reported that Sirtuin 1 (SIRT1) as well as ADP-ribosyltransferase and deacetylase may influence CML cell viability and inflammation.

Pubmed ID: 32165863

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