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Sophoridine inhibits lung cancer cell growth and enhances cisplatin sensitivity through activation of the p53 and Hippo signaling pathways.

Lingling Zhu | Shanshan Huang | Junhe Li | Jun Chen | Yangyang Yao | Li Li | Hui Guo | Xiaojun Xiang | Jun Deng | Jianping Xiong
Gene | 2020

Sophoridine, a quinolizidine alkaloid extracted from the Chinese herb Sophora alopecuroides L., has been reported to exert antitumor effects against multiple human cancers. However, few studies have evaluated its tumor-suppressing effects and associated mechanism with respect to lung cancer, in addition to its potential to be used for clinical lung cancer treatment.

Pubmed ID: 32165304

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A-549 (tool)

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

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