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m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma.

Li Liu | Jing Wang | Guifeng Sun | Qiong Wu | Ji Ma | Xin Zhang | Nan Huang | Zhixuan Bian | Song Gu | Min Xu | Minzhi Yin | Fenyong Sun | Qiuhui Pan
Molecular cancer | 2019

N6-Methyladenosine (m6A) modification has been implicated in many biological processes. It is important for the regulation of messenger RNA (mRNA) stability, splicing, and translation. However, its role in cancer has not been studied in detail. Here we investigated the biological role and underlying mechanism of m6A modification in hepatoblastoma (HB).

Pubmed ID: 31870368

Research resources used in this publication

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Antibodies used in this publication

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Associated grants

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ATCC (tool)

RRID:SCR_001672

Global nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.

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SPSS (tool)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

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Abcam (tool)

RRID:SCR_012931

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BD Biosciences (tool)

RRID:SCR_013311

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Synaptic Systems (tool)

RRID:SCR_013612

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HEK293T (tool)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

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Hep-G2 (tool)

RRID:CVCL_0027

Cell line Hep-G2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HuH-6 (tool)

RRID:CVCL_4381

Cell line HuH-6 is a Cancer cell line with a species of origin Homo sapiens (Human)

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L-02 (tool)

RRID:CVCL_6926

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