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Epigenetically upregulated GEFT-derived invasion and metastasis of rhabdomyosarcoma via epithelial mesenchymal transition promoted by the Rac1/Cdc42-PAK signalling pathway.

Chunxia Liu | Liang Zhang | Wenwen Cui | Juan Du | Zhenzhen Li | Yuwen Pang | Qianqian Liu | Hao Shang | Lian Meng | Wanyu Li | Lingxie Song | Ping Wang | Yuwen Xie | Yuanyuan Wang | Yang Liu | Jianming Hu | Wenjie Zhang | Feng Li
EBioMedicine | 2019

Metastasis of rhabdomyosarcoma (RMS) is the primary cause of tumour-related deaths. Previous studies have shown that overexpression of the guanine nucleotide exchange factor T (GEFT) is correlated with a poorer RMS prognosis, but the mechanism remains largely unexplored.

Pubmed ID: 31761617

Research resources used in this publication

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Associated grants

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FlowJo (tool)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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QIAGEN (tool)

RRID:SCR_008539

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Millipore (tool)

RRID:SCR_008983

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Abcam (tool)

RRID:SCR_012931

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BD Biosciences (tool)

RRID:SCR_013311

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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Rh30 (tool)

RRID:CVCL_0041

Cell line Rh30 is a Cancer cell line with a species of origin Homo sapiens (Human)

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