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EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure.

Quan Zhou | Guijun Yan | Lijun Ding | Jingyu Liu | Xiaoying Yu | Shuangbo Kong | Mei Zhang | Zhilong Wang | Yang Liu | Yue Jiang | Na Kong | Jianxin Sun | Haixiang Sun
EBioMedicine | 2019

Recurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic and transcytotic activity in the endometrium are crucial for decidualization. The most representative endocytic gene is the C-terminal Eps15 homology domain-containing 1 (EHD1), but whether EHD1-mediated endocytic function is responsible for embryo implantation during decidualization remains unclear.

Pubmed ID: 31707150

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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RRID:SCR_012773

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