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Publication

SPARCL1 impedes trophoblast migration and invasion by down-regulating ERK phosphorylation and AP-1 production and altering EMT-related molecule expression.

Xiaojing Liu | Jun Zhao | Xiaorui Luan | Shang Li | Junyu Zhai | Jiansheng Liu | Yanzhi Du
Placenta | 2020

Embryo implantation depends on trophoblast cells migration and invasion. Abnormal function of trophoblast cells could result in many pregnancy complications. Secreted protein acidic and rich in cysteine like-1 (SPARCL1) has been reported to inhibit cell migration and tumor invasion. This study aimed to explore the role of SPARCL1 in trophoblast functions.

Pubmed ID: 31675488

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HTR-8/SVneo (tool)

RRID:CVCL_7162

Cell line HTR-8/SVneo is a Transformed cell line with a species of origin Homo sapiens (Human)

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About

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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