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Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block.

Hemant Suryawanshi | Robert Clancy | Pavel Morozov | Marc K Halushka | Jill P Buyon | Thomas Tuschl
Cardiovascular research | 2020

Investigating human heart development and applying this to deviations resulting in disease is incomplete without molecular characterization of the cell types required for normal functioning. We investigated foetal human heart single-cell transcriptomes from mid-gestational healthy and anti-SSA/Ro associated congenital heart block (CHB) samples.

Pubmed ID: 31589297

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NICHD NIH HHS, United States
    Id: R01 HD079951
  • Agency: NICHD NIH HHS, United States
    Id: R03 HD069986
  • Agency: NIAMS NIH HHS, United States
    Id: R37 AR042455
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR001866

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This is a list of tools and resources that we have found mentioned in this publication.


Systems Transcriptional Activity Reconstruction (tool)

RRID:SCR_005622

A next-generation web-based application that aims to provide an integrated solution for both visualization and analysis of deep-sequencing data, along with simple access to public datasets.

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Seurat (tool)

RRID:SCR_016341

Software as R package designed for QC, analysis, and exploration of single cell RNA-seq data. Enable users to identify and interpret sources of heterogeneity from single cell transcriptomic measurements, and to integrate diverse types of single cell data.

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