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Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway.

Yanjun Wang | Bo Pang | Rui Zhang | Yibing Fu | Qi Pang
Drug design, development and therapy | 2019

Ubenimex, an aminopeptidase N (APN) inhibitor, is widely known for its use as an adjunct therapy for cancer therapy. However, in recent studies, it has also conferred antitumour effects in many cancers, but its anticancer mechanism is largely unknown. This study aims to investigate the specific anticancer activities and mechanisms of ubenimex in GH3 and MMQ cells.

Pubmed ID: 31571825

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Cell Signaling Technology (tool)

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