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Publication

Targeting EZH2 Enhances Antigen Presentation, Antitumor Immunity, and Circumvents Anti-PD-1 Resistance in Head and Neck Cancer.

Liye Zhou | Tenny Mudianto | Xiaojing Ma | Rachel Riley | Ravindra Uppaluri
Clinical cancer research : an official journal of the American Association for Cancer Research | 2020

Anti-programmed death-1 (PD-1) receptor-based therapeutics improve survival in patients with recurrent head and neck squamous cell carcinoma (HNSCC), but many do not benefit due to a low response rate. Herein, we identified EZH2 as a therapeutic target that enhanced tumor cell antigen presentation and subsequently sensitized resistant tumors to anti-PD-1 therapy.

Pubmed ID: 31562203

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Associated grants

  • Agency: NIDCR NIH HHS, United States
    Id: R01 DE024403
  • Agency: NIDCR NIH HHS, United States
    Id: R01 DE027736

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lentiCas9-Blast (tool)

RRID:Addgene_52962

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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