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DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation.

Haoran Cui | Qin Wang | Zhenchuan Lei | Maoxiao Feng | Zhongxi Zhao | Yunshan Wang | Guangwei Wei
Journal of experimental & clinical cancer research : CR | 2019

Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may involve in the process of cancer development. Programmed cell death 4 (PDCD4) is a tumor suppressor gene involved in cell apoptosis, transformation, invasion and tumor progression.

Pubmed ID: 31409387

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