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Publication

The dipeptidyl peptidase 4 inhibitor sitagliptin improves oxidative stress and ameliorates glomerular lesions in a rat model of type 1 diabetes.

Catarina Marques | Andreia Gonçalves | Patrícia Manuela Ribeiro Pereira | Daniela Almeida | Beatriz Martins | Carlos Fontes-Ribeiro | Flávio Reis | Rosa Fernandes
Life sciences | 2019

Oxidative stress has been linked to the development and progression of diabetic nephropathy (DN). The present study evaluated whether the dipeptidyl peptidase-4 inhibitor sitagliptin attenuates glomerular lesions and oxidative stress evoked by chronic hyperglycemia, by a mechanism independent of insulin secretion and glycemia normalization.

Pubmed ID: 31398418

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WI (tool)

RRID:RGD_13508588

Rattus norvegicus with name WI from RGD.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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