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Publication

Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats.

Ibrahim M Shokry | Connor J Shields | John J Callanan | Zhiyuan Ma | Rui Tao
BMC pharmacology & toxicology | 2019

MDMA causes serotonin (5-HT) syndrome immediately after administration and serotonergic injury in a few days or weeks. However, a serotonin syndrome is not always followed by serotonergic injury, indicating different mechanisms responsible for two adverse effects. The goal of present study was to determine causes for two adverse events and further test that dose and environment have a differential role in initiating and intensifying MDMA neurotoxicity.

Pubmed ID: 31383036

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Associated grants

  • Agency: NIDA NIH HHS, United States
    Id: R15 DA029863

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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