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Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential.

Meri Vattulainen | Tanja Ilmarinen | Laura Koivusalo | Keijo Viiri | Heidi Hongisto | Heli Skottman
Stem cell research & therapy | 2019

The differentiation of corneal limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) has great power as a novel treatment for ocular surface reconstruction and for modeling corneal epithelial renewal. However, the lack of profound understanding of the true LSC population identity and the regulation of LSC homeostasis is hindering the full therapeutic potential of hPSC-derived LSCs as well as primary LSCs.

Pubmed ID: 31383008

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GraphPad Prism (tool)

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BD Biosciences (tool)

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RRID:SCR_014199

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