Searching the Resource Information Network

Our searching services are busy right now. Please try again later

  • Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Publication

Mimetic sHDL nanoparticles: A novel drug-delivery strategy to target triple-negative breast cancer.

Ton Wang | Chitra Subramanian | Minzhi Yu | Peter T White | Rui Kuai | Jaquelyn Sanchez | James J Moon | Barbara N Timmermann | Anna Schwendeman | Mark S Cohen
Surgery | 2019

Withanolides are naturally derived heat shock protein 90 inhibitors that are potent in preclinical models of triple negative breast cancers. Conjugation to synthetic high-density lipoprotein nanoparticles improves solubility and targets delivery to the scavenger receptor B1. Triple negative breast cancers highly overexpress the scavenger receptor B1, and we hypothesize that encapsulation of the novel withalongolide A 4,19,27-triacetate by synthetic high-density lipoprotein will have enhanced efficacy against triple negative breast cancers in vivo.

Pubmed ID: 31371177

Research resources used in this publication

None found

Additional research tools detected in this publication

Antibodies used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM113832
  • Agency: NCI NIH HHS, United States
    Id: P30 CA046592
  • Agency: NCI NIH HHS, United States
    Id: R01 CA173292
  • Agency: NCI NIH HHS, United States
    Id: R01 CA210273
  • Agency: NINDS NIH HHS, United States
    Id: R21 NS111191
  • Agency: NCI NIH HHS, United States
    Id: R01 CA216919
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM007544
  • Agency: NCI NIH HHS, United States
    Id: U01 CA120458
  • Agency: NCI NIH HHS, United States
    Id: T32 CA009672

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

MDA-MB-231 (tool)

RRID:CVCL_0062

Cell line MDA-MB-231 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

NCI-H295R (tool)

RRID:CVCL_0458

Cell line NCI-H295R is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

MCF-7 (tool)

RRID:CVCL_0031

Cell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

Jurkat (tool)

RRID:CVCL_0065

Cell line Jurkat is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

SUM159PT (tool)

RRID:CVCL_5423

Cell line SUM159PT is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

About

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

Recent News Entries

Contact Us

Maryann Martone, Ph.D.

Department of Neurosciences, School of Medicine

University of California, San Diego

About SciCrunch | Privacy Policy | Terms of Service

SciCrunch