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Amplicon-based microbiome study highlights the loss of diversity and the establishment of a set of species in patients with dentin caries.

Diana Wolff | Cornelia Frese | Kyrill Schoilew | Alexander Dalpke | Bjoern Wolff | Sébastien Boutin
PloS one | 2019

To elicit patterns in pathogenic biofilm composition we characterized the oral microbiome present in patients with dentin caries in comparison to healthy subjects.

Pubmed ID: 31365560

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This is a list of tools and resources that we have found mentioned in this publication.


QIAGEN (tool)

RRID:SCR_008539

A commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.

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mothur (tool)

RRID:SCR_011947

An open-source software package for describing and comparing microbial communities. It incorporates the functionality of a number of computational tools, calculators, and visualization tools.

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LEfSe (tool)

RRID:SCR_014609

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Algorithm for high-dimensional biomarker discovery and explanation that identifies genes, pathways, or taxa characterizing the differences between two or more biological conditions. The algorithm identifies features that are statistically different among biological classes, then performs additional tests to assess whether these differences are consistent with respect to expected biological behavior. Statistical significance and biological relevance are emphasized.

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