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Publication

The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex.

Magdalena Gierula | Isabelle I Salles-Crawley | Salvatore Santamaria | Adrienn Teraz-Orosz | James T B Crawley | David A Lane | Josefin Ahnström
Journal of thrombosis and haemostasis : JTH | 2019

Activated protein C (APC)-mediated inactivation of factor (F)Va is greatly enhanced by protein S. For inactivation to occur, a trimolecular complex among FVa, APC, and protein S must form on the phospholipid membrane. However, direct demonstration of complex formation has proven elusive.

Pubmed ID: 31364267

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Associated grants

  • Agency: British Heart Foundation, United Kingdom
    Id: PG/14/90/31219
  • Agency: British Heart Foundation, United Kingdom
    Id: PG/14/63/31036
  • Agency: British Heart Foundation, United Kingdom
    Id: FS/10/004/28165
  • Agency: British Heart Foundation, United Kingdom
    Id: PG/17/42/33039
  • Agency: British Heart Foundation, United Kingdom
    Id: FS/12/60/29874
  • Agency: British Heart Foundation, United Kingdom
    Id: RG/18/3/33405

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Dako (tool)

RRID:SCR_013530

An Antibody supplier; Dako was purchased by Agilent in 2012 and several years later the websites began to reflect the Dako products as part of the Agilent catalog.

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HEK293 (tool)

RRID:CVCL_0045

Cell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)

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