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Liraglutide in combination with metformin may improve the atherogenic lipid profile and decrease C-reactive protein level in statin treated obese patients with coronary artery disease and newly diagnosed type 2 diabetes: A randomized trial.

Christian Anholm | Preman Kumarathurai | Lene Rørholm Pedersen | Amirsalar Samkani | Rosemary L Walzem | Olav Wendelboe Nielsen | Ole Peter Kristiansen | Mogens Fenger | Sten Madsbad | Ahmad Sajadieh | Steen Bendix Haugaard
Atherosclerosis | 2019

Atherosclerosis in obesity and type 2 diabetes (T2DM) is associated with low-grade inflammation (LGI) and dyslipidemia, where especially small, dense lipoprotein particles are atherogenic. The glucagon-like peptide-1 receptor agonist, liraglutide, reduces cardiovascular events by poorly understood mechanisms. We investigated the effect of liraglutide combined with metformin on LGI and lipoprotein density profiles in patients with stable coronary artery disease (CAD) and newly diagnosed T2DM.

Pubmed ID: 31326727

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