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Delayed immune-related events (DIRE) after discontinuation of immunotherapy: diagnostic hazard of autoimmunity at a distance.

Marcus A Couey | R Bryan Bell | Ashish A Patel | Meghan C Romba | Marka R Crittenden | Brendan D Curti | Walter J Urba | Rom S Leidner
Journal for immunotherapy of cancer | 2019

The risk of delayed autoimmunity occurring months or years after discontinuation of immunotherapy is frequently asserted in the literature. However, specific cases were rarely described until 2018, when a wave of reports surfaced. With expanding I-O indications in the adjuvant/neoadjuvant curative setting, growing numbers of patients will receive limited courses of immunotherapy before entering routine surveillance. In this context, under-recognition of DIRE could pose a growing clinical hazard.

Pubmed ID: 31269983

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