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Growth environment and organ specific variation in in-vitro cytoprotective activities of Picea mariana in PC12 cells exposed to glucose toxicity: a plant used for treatment of diabetes symptoms by the Cree of Eeyou Istchee (Quebec, Canada).

Ashleigh D Downing | Hoda M Eid | Andrew Tang | Fida Ahmed | Cory S Harris | Pierre S Haddad | Timothy Johns | John T Arnason | Steffany A L Bennett | Alain Cuerrier
BMC complementary and alternative medicine | 2019

The Cree of Eeyou Istchee (James Bay area of northern Quebec) suffer from a high rate of diabetes and its complications partly due to the introduction of the western lifestyle within their culture. As part of a search for alternative medicine based on traditional practice, this project evaluates the biological activity of Picea mariana (Mill.) Britton, Sterns & Poggenb. needle, bark, and cone, in preventing glucose toxicity to PC12-AC cells in vitro (a diabetic neurophathy model) and whether habitat and growth environment influence this activity.

Pubmed ID: 31215420

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