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The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated HVEM-expressing B cell responses independently of B-cell-intrinsic signaling via HVEM or BTLA. BTLA signaling into T cells through the phosphatase SHP1 reduced T cell receptor (TCR) signaling and preformed CD40 ligand mobilization to the immunological synapse, thus diminishing the help delivered to B cells. Moreover, T cell deficiency in BTLA cooperated with B cell Bcl-2 overexpression, leading to GC B cell outgrowth. These results establish that HVEM restrains the T helper signals delivered to B cells to influence GC selection outcomes, and they suggest that BTLA functions as a cell-extrinsic suppressor of GC B cell lymphomagenesis.
Pubmed ID: 31204070
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A web-based gene list enrichment analysis tool that provides various types of visualization summaries of collective functions of gene lists. It includes new gene-set libraries, an alternative approach to rank enriched terms, and various interactive visualization approaches to display enrichment results using the JavaScript library, Data Driven Documents (D3). The software can also be embedded into any tool that performs gene list analysis. System-wide profiling of genes and proteins in mammalian cells produce lists of differentially expressed genes / proteins that need to be further analyzed for their collective functions in order to extract new knowledge. Once unbiased lists of genes or proteins are generated from such experiments, these lists are used as input for computing enrichment with existing lists created from prior knowledge organized into gene-set libraries.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE.Documented on January 4,2023. IgBLAST was developed at NCBI to facilitate analysis of immunoglobulin V region sequences in GenBank. In addition to performing a regular BLAST search, IgBLAST has several additional functions: - Reports the germline V, D and J gene matches to the query sequence. - Annotates the immunoglobulin domains (FWR1 through FWR3). - Matches the returned hits (for databases other than germline genes) to the closest germline V genes, making it easier to identify related sequences. - Reveals the V(D)J junction details such as nucleotide homology between the ends of V(D)J segments and N nucleotide insertions. D and J gene reporting is only for nucleotide sequence search and requires a stretch of five or more nucleotide identity between the query and D or J genes. Sponsors: This resource is supported by the National Center for Biotechnology Information, a division of the U.S. National Library of Medicine.
View all literature mentionsCommercial organization which provides life science services and products to researchers. They specialize in gene synthesis, peptide, protein, antibody and preclinical drug development service.
View all literature mentionsSoftware package for interpreting gene expression data. Used for interpretation of a large-scale experiment by identifying pathways and processes.
View all literature mentionsPrivately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related reagents used to study cell signaling pathways that impact human health.
View all literature mentionsCommercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsVector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
View all literature mentionsSoftware package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.
View all literature mentionsCell sorter features hardware and software enhancements that improve overall ease of use, flexibility,and aseptic capability. Offers new options in lasers and nozzles to support more advanced multicolor applications. Built on fixed alignment technology. FACSAria II cell sorter is first generation of BD FACSAria system where flow cell is in true fixed alignment with laser, to reduce startup time and improve reproducibility.
View all literature mentionsSoftware package that integrates genome wide genetic variation with epigenetic data to identify collaborative transcription factor pairs. Optimized to work with chromatin accessibility assays such as ATAC-seq or DNase I hypersensitivity, as well as transcription factor binding data collected by ChIP-seq. Used to identify combinations of cell type specific transcription factors while simultaneously interpreting functional effects of non-coding genetic variation.
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Mus musculus with name B6.SJL-Ptprca Pepc
Mus musculus with name B6.129P2(Cg)-Ighg1tm1(cre)Cgn Igk
Mus musculus with name B6.SJL-Ptprca Pepc
This monoclonal targets CD279
View all literature mentionsThis polyclonal targets Phospho-Zap-70 (Tyr493)
View all literature mentionsThis monoclonal targets CD185
View all literature mentionsThis unknown targets PKC theta, phospho (Thr538)
View all literature mentionsThis monoclonal targets Mouse CD45.2
View all literature mentionsThis monoclonal targets GL7
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD270 (HVEM)
View all literature mentionsThis monoclonal targets CD20
View all literature mentionsThis monoclonal targets CD73
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets CD272
View all literature mentionsThis monoclonal targets TCR Vα2
View all literature mentionsThis monoclonal targets CD279
View all literature mentionsThis monoclonal targets CD95
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis polyclonal targets PTPN6
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets IgG1
View all literature mentionsThis monoclonal targets CD279
View all literature mentionsThis polyclonal targets Mouse Ephrin-B1
View all literature mentionsThis monoclonal targets CD279
View all literature mentionsThis polyclonal targets PTPN11
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD272
View all literature mentionsThis monoclonal targets Caspase 3, Active Form
View all literature mentionsThis monoclonal targets TCR beta chain
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets CD138
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets CD270 (HVEM)
View all literature mentionsThis monoclonal targets CD185
View all literature mentionsMus musculus with name B6.129P2(Cg)-Ighg1tm1(cre)Cgn/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2-Ptpn6tm1Rsky/J from IMSR.
View all literature mentionsMus musculus with name B6;SJL-Tnfrsf14tm1.1Kro/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2-Tcrbtm1Mom/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Rag2tm1.1Cgn/J from IMSR.
View all literature mentionsMus musculus with name B6.C(Cg)-Cd79atm1(cre)Reth/EhobJ from IMSR.
View all literature mentionsMus musculus with name STOCK Ptpn11tm1.1Wbm/J from IMSR.
View all literature mentionsMus musculus with name B6.129S(FVB)-Bcl6tm1.1Dent/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(BCL2)22Wehi/J from IMSR.
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