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Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study.

Caigui Lin | Zhong Chen | Lingqiang Zhang | Zhiliang Wei | Kian-Kai Cheng | Yueyue Liu | Guiping Shen | Haining Fan | Jiyang Dong
Parasites & vectors | 2019

Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (1H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE.

Pubmed ID: 31196218

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