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Publication

High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia.

Wen Du | Jing He | Wei Zhou | Simin Shu | Juan Li | Wei Liu | Yun Deng | Cong Lu | Shengyan Lin | Yaokun Ma | Yanli He | Jine Zheng | Jiang Zhu | Lijuan Bai | Xiaoqing Li | Junxia Yao | Dan Hu | Shengqing Gu | Huiyu Li | Anyuan Guo | Shiang Huang | Xiaolan Feng | Dong Hu
Journal of translational medicine | 2019

Elevated protein expressions of CD markers such as IL2RA/CD25, CXCR4/CD184, CD34 and CD56 are associated with adverse prognosis in acute myeloid leukemia (AML). However, the prognostic value of mRNA expressions of these CD markers in AML remains unclear. Through our pilot evaluation, IL2RA mRNA expression appeared to be the best candidate as a prognostic biomarker. Therefore, the aim of this study is to characterize the prognostic value of IL2RA mRNA expression and evaluate its potential to refine prognostification in AML.

Pubmed ID: 31171000

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Thermo Fisher Scientific (tool)

RRID:SCR_008452

Commercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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