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Publication

Shear-Stress Sensitive Inwardly-Rectifying K+ Channels Regulate Developmental Retinal Angiogenesis by Vessel Regression.

Evgenii Boriushkin | Ibra S Fancher | Irena Levitan
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2019

Shear stress plays major roles in developmental angiogenesis, particularly in blood vessel remodeling and maturation but little is known about the shear stress sensors involved in this process. Our recent study identified endothelial Kir2.1 channels as major contributors to flow-induced vasodilation, a hallmark of the endothelial flow response. The goal of this study is to establish the role of Kir2.1 in the regulation of retinal angiogenesis.

Pubmed ID: 31145841

Research resources used in this publication

None found

Additional research tools detected in this publication

Antibodies used in this publication

None found

Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL073965
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL083298
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL113570
  • Agency: NIH HHS, United States
    Id: HL-113570, HL-073965, HL-083298

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

w[*]; P{w[+mC]=QUAS-Kir2.1.P}3/CyO (tool)

RRID:BDSC_91802

Drosophila melanogaster with name w[*]; P{w[+mC]=QUAS-Kir2.1.P}3/CyO from BDSC.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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