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Understanding the precise relation between functional connectivity and structural (white matter) connectivity and how these relationships account for cognitive changes in older adults are major challenges for neuroscience. We investigate these issues using an approach in which structural equation modeling (SEM) is employed to integrate functional and structural connectivity data from younger and older adults (n = 62), analyzed with a common framework based on regions connected by canonical tract groups (CTGs). CTGs (e.g., uncinate fasciculus) serve as a common currency between functional and structural connectivity matrices, and ensure equivalent sparsity in connectome information. We used this approach to investigate the neural mechanisms supporting memory for items and memory for associations, and how they are affected by healthy aging. We found that different structural and functional CTGs made independent contributions to source and item memory performance, suggesting that both forms of connectivity underlie age-related differences in specific forms of memory. Furthermore, the relationship between functional and structural connectivity was best explained by a general relationship between latent constructs-a relationship absent in any specific CTG group. These results provide insights into the relationship between structural and functional connectivity patterns, and elucidate their relative contribution to age-related differences in source memory performance.
Pubmed ID: 31139760
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Data analysis service to predict whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. SIFT can be applied to naturally occurring nonsynonymous polymorphisms and laboratory-induced missense mutations. (entry from Genetic Analysis Software) Web service is also available.
View all literature mentionsMATLAB Toolbox for presenting stimuli and recording responses with precise timing. It also provides additional utilities for the manipulation of sound, keyboard, mouse, joystick, serial port, parallel port, subject responses and physiological monitoring hardware.
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