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The influence of zoledronate and teriparatide on gamma delta T cells in mice.

Eiki Yamachika | Yuichi Matsui | Masakazu Matsubara | Tatsushi Matsumura | Naoki Nakata | Norifumi Moritani | Atsushi Ikeda | Hidetsugu Tsujigiwa | Naoya Ohara | Seiji Iida
Journal of dental sciences | 2017

Few studies have investigated the possibility that bisphosphonate-related osteonecrosis of the jaw (BRONJ) might reflect an immune response; however, gamma delta T cells have been shown to significantly decline in the blood of BRONJ patients. Additionally, there have been some reports of teriparatide usage for the treatment of BRONJ. In this study, we compared the effects of zoledronate and teriparatide on lymphocyte populations and inflammatory cytokine production in mice.

Pubmed ID: 30895072

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FlowJo (tool)

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Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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Abcam (tool)

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A commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.

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