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Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury.

Yue Zhou | Pengfei Li | Andrew J Goodwin | James A Cook | Perry V Halushka | Eugene Chang | Basilia Zingarelli | Hongkuan Fan
Critical care (London, England) | 2019

The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar space. We previously found that endothelial progenitor cell (EPC) exosomes prevent endothelial dysfunction and lung injury in sepsis in part due to their encapsulation of miRNA-126. However, the effects of EPC exosomes in acute lung injury (ALI) remain unknown.

Pubmed ID: 30760290

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NCATS NIH HHS, United States
    Id: 5TL1TR001451
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM130653
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM113995
  • Agency: NIGMS NIH HHS, United States
    Id: 1R01GM130653
  • Agency: NHLBI NIH HHS, United States
    Id: K23 HL135263
  • Agency: NCI NIH HHS, United States
    Id: P30 CA138313
  • Agency: NIGMS NIH HHS, United States
    Id: 1R01GM113995
  • Agency: NCATS NIH HHS, United States
    Id: TL1 TR001451
  • Agency: NHLBI NIH HHS, United States
    Id: 1K23HL135263-01A1
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR001450

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GraphPad Prism (tool)

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RRID:SCR_012931

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