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Most evolutionary analyses are based on pre-estimated multiple sequence alignment. Wong et al. established the existence of an uncertainty induced by multiple sequence alignment when reconstructing phylogenies. They were able to show that in many cases different aligners produce different phylogenies, with no simple objective criterion sufficient to distinguish among these alternatives.
Pubmed ID: 30726875
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Software program for phylogenetic analyses of large datasets under maximum likelihood.
View all literature mentionsEfficient protein multiple sequence alignment program, which has demonstrated a statistically significant improvement in accuracy compared to several leading alignment tools.
View all literature mentionsA multiple sequence alignment server which can align Protein, DNA and RNA sequences.
View all literature mentionsWeb sevice of ClustalW provided by DNA data bank of Japan.
View all literature mentions