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Publication

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours.

Valentina Martin | Cristina Chiriaco | Chiara Modica | Anna Acquadro | Marco Cortese | Francesco Galimi | Timothy Perera | Loretta Gammaitoni | Massimo Aglietta | Paolo M Comoglio | Elisa Vigna | Dario Sangiolo
British journal of cancer | 2019

Interferon-induced expression of programmed cell death ligands (PD-L1/PD-L2) may sustain tumour immune-evasion. Patients featuring MET amplification, a genetic lesion driving transformation, may benefit from anti-MET treatment. We explored if MET-targeted therapy interferes with Interferon-γ modulation of PD-L1/PD-L2 in MET-amplified tumours.

Pubmed ID: 30723303

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Jackson ImmunoResearch (tool)

RRID:SCR_010488

A commercial antibody vendor, specializing in secondary antibodies.

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MKN45 (tool)

RRID:CVCL_0434

Cell line MKN45 is a Cancer cell line with a species of origin Homo sapiens (Human)

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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