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Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.

Mustafa F Alkhouli | Jun Hung | Michaela Squire | Miranda Anderson | Monica Castro | Jeganathan R Babu | Layla Al-Nakkash | Tom L Broderick | Jeffrey H Plochocki
BMC complementary and alternative medicine | 2019

Alzheimer's disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. In this study, we test the hypothesis that these treatments improve fracture resistance in a mouse model representative of the AD condition.

Pubmed ID: 30717730

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B6;129-Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm/Mmjax (tool)

RRID:MMRRC_034830-JAX

Mus musculus with name B6;129-Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm/Mmjax from MMRRC.

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