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AluYb8 insertion polymorphism in the MUTYH gene impairs mitochondrial DNA maintenance and affects the age of onset of IPF.

Wei Zhou | Jiapeng Sun | Wenwen Guo | Yi Zhuang | Lizhi Xu | Yaping Wang
Aging | 2019

Idiopathic pulmonary fibrosis (IPF) is an age-related fatal disease with an unknown etiology. Increased oxidative stress and mitochondrial dysfunction are thought to be involved in its pathogenesis. However, the effect of the AluYb8MUTYH polymorphism on IPF is not known.

Pubmed ID: 30716719

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