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Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosis.

Eva Pigna | Elena Simonazzi | Krizia Sanna | Krzysztof Marian Bernadzki | Tomek Proszynski | Constantin Heil | Daniela Palacios | Sergio Adamo | Viviana Moresi
EBioMedicine | 2019

Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the disease. However, our recent studies on the skeletal muscle response upon long-term denervation highlighted the importance of HDAC4 in maintaining muscle integrity.

Pubmed ID: 30713114

Associated grants

None

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Charles River Laboratories (tool)

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