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Association of Retinal Nerve Fiber Layer Thickness With Brain Alterations in the Visual and Limbic Networks in Elderly Adults Without Dementia.

Juan Luis Méndez-Gómez | Amandine Pelletier | Marie-Bénédicte Rougier | Jean-François Korobelnik | Cédric Schweitzer | Marie-Noëlle Delyfer | Gwenaëlle Catheline | Solène Monfermé | Jean-François Dartigues | Cécile Delcourt | Catherine Helmer
JAMA network open | 2018

The eye is a sensory organ that is easily accessible for imaging techniques, allowing the measurement of the retinal nerve fiber layer (RNFL) thickness. The eye is part of the central nervous system, and its neurons may be susceptible to degeneration; therefore, changes in the RNFL thickness may reflect microstructural and volume alterations in the brain.

Pubmed ID: 30646353

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VBM toolbox (tool)

RRID:SCR_014196

A collection of extensions to the segmentation algorithm of SPM2, SPM5, and SPM8 to provide voxel-based morphometry. The toolboxes are named according to the SPM version. The software is available to the scientific community under the terms of the GNU General Public License. VBM subpages can be accessed from the VBM website.

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