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Zika virus induces strong inflammatory responses and impairs homeostasis and function of the human retinal pigment epithelium.

Yannick Simonin | Nejla Erkilic | Krishna Damodar | Marion Clé | Caroline Desmetz | Karine Bolloré | Mehdi Taleb | Simona Torriano | Jonathan Barthelemy | Grégor Dubois | Anne Dominique Lajoix | Vincent Foulongne | Edouard Tuaillon | Philippe Van de Perre | Vasiliki Kalatzis | Sara Salinas
EBioMedicine | 2019

Zika virus (ZIKV) has recently re-emerged as a pathogenic agent with epidemic capacities as was well illustrated in South America. Because of the extent of this health crisis, a number of more serious symptoms have become associated with ZIKV infection than what was initially described. In particular, neuronal and ocular disorders have been characterized, both in infants and in adults. Notably, the macula and the retina can be strongly affected by ZIKV, possibly by a direct effect of the virus. This is supported by the detection of replicative and infectious virus in lachrimal fluid in human patients and mouse models.

Pubmed ID: 30579862

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