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GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization.

Hung-I Harry Chen | Yu-Chiao Chiu | Tinghe Zhang | Songyao Zhang | Yufei Huang | Yidong Chen
BMC systems biology | 2018

Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set based analyses improve the biologists' capability to discover functional relevance of their experiment design. While elucidating gene set individually, inter-gene sets association is rarely taken into consideration. Deep learning, an emerging machine learning technique in computational biology, can be used to generate an unbiased combination of gene set, and to determine the biological relevance and analysis consistency of these combining gene sets by leveraging large genomic data sets.

Pubmed ID: 30577835

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA054174
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM113245
  • Agency: NCRR NIH HHS, United States
    Id: UL1 RR025767

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This is a list of tools and resources that we have found mentioned in this publication.


Gene Set Enrichment Analysis (tool)

RRID:SCR_003199

Software package for interpreting gene expression data. Used for interpretation of a large-scale experiment by identifying pathways and processes.

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UCSC Cancer Genomics Browser (tool)

RRID:SCR_011796

A suite of web-based tools to visualize, integrate and analyze cancer genomics and its associated clinical data. It is possible to display your own clinical data within one of their datasets.

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clValid (tool)

RRID:SCR_014626

An R package which contains functions for validating the results of a clustering analysis.

View all literature mentions