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SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.

Ziming Li | Jia Huang | Shengping Shen | Zhenping Ding | Qingquan Luo | Zhiwei Chen | Shun Lu
Journal of experimental & clinical cancer research : CR | 2018

Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known to promote metastasis of non-small cell lung cancer (NSCLC).

Pubmed ID: 30577808

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