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Opposing roles of inter-α-trypsin inhibitor heavy chain 4 in recurrent pregnancy loss.

Lan Li | Bum-Chae Choi | Ji Eun Ryoo | Sang-Jin Song | Chang-Zhu Pei | Kwang Yul Lee | Jinyoung Paek | Kwang-Hyun Baek
EBioMedicine | 2018

The mechanism behind an increased risk of recurrent pregnancy loss (RPL) remains largely unknown. In our previous study, we identified that inter-α-trypsin inhibitor heavy chain 4 (ITI-H4) is highly expressed at a modified molecular weight of 36 kDa in serum derived from RPL patients. Yet, the precise molecular mechanism and pathways by which the short form of ITI-H4 carries out its function remain obscure.

Pubmed ID: 30348621

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