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Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo.

Xiao-Heng Zhao | Franklin R Tay | Yan-Jun Fang | Liu-Yan Meng | Zhuan Bian
Archives of oral biology | 2019

Gingival recession and alveolar bone loss are common manifestations of periodontitis. Periodontal regeneration is the ideal strategy for rehabilitating periodontal tissue defects and preventing tooth loss. The present study examined whether localized, topical application of gingival overgrowth-inducing drugs, phenytoin, nifedipine or cyclosporine, induces periodontal regeneration.

Pubmed ID: 30342306

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