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A Longitudinal Model of Human Neuronal Differentiation for Functional Investigation of Schizophrenia Polygenic Risk.

Anil P S Ori | Merel H M Bot | Remco T Molenhuis | Loes M Olde Loohuis | Roel A Ophoff
Biological psychiatry | 2019

Common psychiatric disorders are characterized by complex disease architectures with many small genetic effects that contribute and complicate biological understanding of their etiology. There is therefore a pressing need for in vitro experimental systems that allow for interrogation of polygenic psychiatric disease risk to study the underlying biological mechanisms.

Pubmed ID: 30340753

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Associated grants

  • Agency: NIMH NIH HHS, United States
    Id: R01 MH090553
  • Agency: NIMH NIH HHS, United States
    Id: U01 MH105578

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betr (tool)

RRID:SCR_001332

Software package that implements the Bayesian Estimation of Temporal Regulation algorithm to identify differentially expressed genes in microarray time-course data.

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GenomeStudio (tool)

RRID:SCR_010973

Visualize and analyze data generated by all of Illumina''s platforms.

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FactoMineR (tool)

RRID:SCR_014602

Software R package for multivariate analysis which takes into account different types of data structure. Data can be organized in groups of variable, groups of individuals, or into hierarchy of variables.

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