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Publication

miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway.

Baojin Wang | Xia Li | Guannan Zhao | Huan Yan | Peixin Dong | Hidemichi Watari | Michelle Sims | Wei Li | Lawrence M Pfeffer | Yuqi Guo | Junming Yue
Journal of experimental & clinical cancer research : CR | 2018

We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer cells by directly targeting transcription factor Snai2 and inhibiting epithelial to mesenchymal transition (EMT), whereas BIRC5/survivin promotes EMT. In this study, we tested our hypothesis that miR-203 inhibits ovarian tumor metastasis by suppressing EMT through targeting BIRC5, using an orthotopic ovarian cancer mouse model.

Pubmed ID: 30241553

Research resources used in this publication

None found

Additional research tools detected in this publication

Antibodies used in this publication

None found

Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA193609
  • Agency: NCI NIH HHS, United States
    Id: R21 CA216585
  • Agency: National Institutes of Health,
    Id: R01CA193609-01A1
  • Agency: National Institue of Health,
    Id: 1R21CA216585-01A1

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This is a list of tools and resources that we have found mentioned in this publication.

OVCAR-3 (tool)

RRID:CVCL_0465

Cell line OVCAR-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

SK-OV-3 (tool)

RRID:CVCL_0532

Cell line SK-OV-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

HEK293 (tool)

RRID:CVCL_0045

Cell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)

View all literature mentions

About

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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University of California, San Diego

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