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Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway.

Fengchen Zhang | Haiping Dong | Tao Lv | Ke Jin | Yichao Jin | Xiaohua Zhang | Jiyao Jiang
Journal of neuroinflammation | 2018

Complex mechanisms participate in microglial activation after a traumatic brain injury (TBI). TBI can induce autophagy and apoptosis in neurons and glial cells, and moderate hypothermia plays a protective role in the acute phase of TBI. In the present study, we evaluated the effect of TBI and moderate hypothermia on microglial activation and investigated the possible roles of autophagy/apoptosis and toll-like receptor 4 (TLR4).

Pubmed ID: 30236124

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