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Publication

Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets.

Chuhyon Corwin | Anastasia Nikolopoulou | Allen L Pan | Mariela Nunez-Santos | Shankar Vallabhajosula | Peter Serrano | John Babich | Maria E Figueiredo-Pereira
Journal of neuroinflammation | 2018

Prostaglandins are products of the cyclooxygenase pathway, which is implicated in Parkinson's disease (PD). Limited knowledge is available on mechanisms by which prostaglandins contribute to PD neurodegeneration. To address this gap, we focused on the prostaglandin PGD2/J2 signaling pathway, because PGD2 is the most abundant prostaglandin in the brain, and the one that increases the most under pathological conditions. Moreover, PGJ2 is spontaneously derived from PGD2.

Pubmed ID: 30236122

Research resources used in this publication

None found

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Antibodies used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: R25 GM060665
  • Agency: NCRR NIH HHS, United States
    Id: UL1 RR024996
  • Agency: National Institutes of Health,
    Id: GM060665, RISE training Program
  • Agency: NIMHD NIH HHS, United States
    Id: G12 MD007599
  • Agency: National Institutes of Health,
    Id: CTSC GRANT UL1-RR024996
  • Agency: Neuroscience Collaborative Program, Graduate Center, CUNY,
    Id: none
  • Agency: National Science Foundation,
    Id: 0965983, IGERT Training Program
  • Agency: National Institutes of Health,
    Id: MD007599

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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