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Publication

Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson's disease: ex vivo and in vitro studies.

Istvan Horvath | Igor A Iashchishyn | Roman A Moskalenko | Chao Wang | Sebastian K T S Wärmländer | Cecilia Wallin | Astrid Gräslund | Gabor G Kovacs | Ludmilla A Morozova-Roche
Journal of neuroinflammation | 2018

Chronic neuroinflammation is a hallmark of Parkinson's disease (PD) pathophysiology, associated with increased levels of pro-inflammatory factors in PD brain tissues. The pro-inflammatory mediator and highly amyloidogenic protein S100A9 is involved in the amyloid-neuroinflammatory cascade in Alzheimer's disease. This is the first report on the co-aggregation of α-synuclein (α-syn) and S100A9 both in vitro and ex vivo in PD brain.

Pubmed ID: 29866153

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Associated grants

  • Agency: LF Västerbotten Läns Landsting,
    Id: ALFVLL-369861
  • Agency: Vetenskapsrådet,
    Id: 2014-3241
  • Agency: Insamlingstiftelsen,
    Id: FS 2.1.12-1605-14
  • Agency: Biochemical Imaging Platform,
    Id: N.A.
  • Agency: Hjärnfonden,
    Id: N.A.
  • Agency: Hjärnfonden,
    Id: N/A
  • Agency: Vetenskapsrådent,
    Id: N/A
  • Agency: FP-7 Marie Curie Action "Nano-Guard",
    Id: 269138
  • Agency: FP-7 Marie Curie Action "Nano-Guard",
    Id: 269138

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SH-SY5Y (tool)

RRID:CVCL_0019

Cell line SH-SY5Y is a Cancer cell line with a species of origin Homo sapiens (Human)

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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