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Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides.

Daisuke Yamamiya | Eishiro Mizukoshi | Kiichiro Kaji | Takeshi Terashima | Masaaki Kitahara | Tatsuya Yamashita | Kuniaki Arai | Kazumi Fushimi | Masao Honda | Shuichi Kaneko
PloS one | 2018

Many individuals are infected with hepatitis B virus (HBV) worldwide, and this virus is commonly controlled by treatments with interferon (IFN)-alpha and nucleoside analogues (NA). However, the complete elimination of HBV by these treatments is difficult and, thus, the development of new treatments is needed. Host immune responses are closely involved in the elimination of HBV, suggesting the usefulness of immunotherapy. In the present study, we attempted to identify novel cytotoxic T-lymphocyte (CTL) epitopes that are useful for immunotherapy against HBV.

Pubmed ID: 29856876

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K-562 (tool)

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K-562 (tool)

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Hep-G2 (tool)

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NOD.129P2(B6)-B2mtm1Unc Tg(HLA-A24/H2-D/B2M)3Dvs/J (tool)

RRID:IMSR_JAX:010565

Mus musculus with name NOD.129P2(B6)-B2mtm1Unc Tg(HLA-A24/H2-D/B2M)3Dvs/J from IMSR.

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