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An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese.

Anne-Sofie Graae | Mette Hollensted | Julie T Kloppenborg | Yuvaraj Mahendran | Theresia M Schnurr | Emil Vincent R Appel | Johanne Rask | Tenna R H Nielsen | Mia Ø Johansen | Allan Linneberg | Marit E Jørgensen | Niels Grarup | Haja N Kadarmideen | Birgitte Holst | Oluf Pedersen | Jens-Christian Holm | Torben Hansen
Diabetologia | 2018

A genetic risk score (GRS) consisting of 53 insulin resistance variants (GRS53) was recently demonstrated to associate with insulin resistance in adults. We speculated that the GRS53 might already associate with insulin resistance during childhood, and we therefore aimed to investigate this in populations of Danish children and adolescents. Furthermore, we aimed to address whether the GRS associates with components of the metabolic syndrome and altered body composition in children and adolescents.

Pubmed ID: 29855666

Research resources used in this publication

None found

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Associated grants

  • Agency: Innovation Fund Denmark, International
    Id: 0603-00484B

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ClinicalTrials.gov (tool)

RRID:SCR_002309

Registry and results database of federally and privately supported clinical trials conducted in United States and around world. Provides information about purpose of trial, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals.Offers information for locating federally and privately supported clinical trials for wide range of diseases and conditions. Research study in human volunteers to answer specific health questions. Interventional trials determine whether experimental treatments or new ways of using known therapies are safe and effective under controlled environments. Observational trials address health issues in large groups of people or populations in natural settings. ClinicalTrials.gov contains trials sponsored by National Institutes of Health, other federal agencies, and private industry. Studies listed in database are conducted in all 50 States and in 178 countries.

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IMPUTE2 (tool)

RRID:SCR_013055

A computer program for phasing observed genotypes and imputing missing genotypes.

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GenomeStudio (tool)

RRID:SCR_010973

Visualize and analyze data generated by all of Illumina''s platforms.

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