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Serum of myeloproliferative neoplasms stimulates hematopoietic stem and progenitor cells.

Richard K Lubberich | Thomas Walenda | Tamme W Goecke | Klaus Strathmann | Susanne Isfort | Tim H Brümmendorf | Steffen Koschmieder | Wolfgang Wagner
PloS one | 2018

Myeloproliferative neoplasms (MPN)-such as polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF)-are typically diseases of the elderly caused by acquired somatic mutations. However, it is largely unknown how the malignant clone interferes with normal hematopoiesis. In this study, we analyzed if serum of MPN patients comprises soluble factors that impact on hematopoietic stem and progenitor cells (HPCs).

Pubmed ID: 29851963

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Miltenyi Biotec (tool)

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